THE EFFECT OF HPMC AS A GEL BASE AND TWEEN 80 SPAN 80 COMBINATIONS AS EMULGATORS IN ACETOSAL TRANSDERMAL EMULGEL PREPARATIONS
Acetosal or acetyl salicylic acid is a crystal beaded candle holder drug that has efficacy as ananalgesic, antipireic, and antiplatelet.Aacetosal undegoes cross-first metabolisism (first pass effect) causing low drug bioavailability.The smal lsolubility of acetosal will affect the rate of absorption which later affect the intensity of treatment, so